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Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger. Pantoprazole: 40 mg once a day: 20 mg once a day * 40 mg twice a day: Rabeprazole: 20 mg once a day: 10 mg once a day * 20 mg twice a day: Esomeprazole † 20 mg once a day: Not available ‡ 40 mg once a day: Doses should be given 30 minutes before breakfast and (if needed) 30 minutes before the evening meal, to provide optimal control of. You can connect with our Estimates team at (608) 775-8660 or email us. If you get your care at a regional hospital or one of their clinics, you can find contact information here. You can also view our patient estimate policy. 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